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Molly Percocet, What Are Molly And Percocet? Side Effects, Effects On The Brain & Popularity

What Is Molly Percocet?

Prescription drugs are often mixed with party drugs like Molly (MDMA) to intensify their side effects. As a highly addictive prescription drug made up of amphetamine and oxycodone, Percocet can produce adverse side effects on its own. When combined with synthetic or hallucinogenic drugs like Molly, the side effects can be life-threatening. This article is about sharing more information about the effects of Molly Percocet and how this drug combo became popular.

Molly Percocet: What is Molly?

According to the National Institute on Drug Abuse, Methylenedioxy-methamphetamine (MDMA) commonly known as Molly, is a synthetic drug that alters mood and perception (awareness of surrounding objects and conditions). It is chemically similar to stimulants and hallucinogens, producing feelings of increased energy, pleasure, emotional warmth, and distorted sensory and time perception. 

It was initially popular in the nightclub scene and at all-night dance parties (“raves”). But the drug now affects a broader range of people, commonly called Ecstasy or Molly. Its chemical structure is similar to amphetamines, such as methamphetamine and a hallucinogen called mescaline. Mescaline is the active ingredient in the drug peyote.

The unique chemical structure of MDMA causes both hallucinogenic and stimulant effects, such as bursts of energy, changes to how time is perceived, and sensitivity to touch.  Ecstasy and Molly come in pills, capsules, and powder. They’re well-known club drugs that are popular at music festivals.

In 2016, an estimated 2.4 million people reported using ecstasy, according to the National Survey on Drug Use and Health published in September 2017. 

Molly Percocet
Molly Percocet: Prescription drugs like Percocet are often mixed with party drugs like Molly (MDMA) to intensify their side effects.

Molly Percocet Effects on the brain 

MDMA increases the activity of three brain chemicals:

  • Dopamine: produces increased energy/activity and acts in the reward system to reinforce behaviors.
  • Norepinephrine: increases heart rate and blood pressure, which are particularly risky for people with heart and blood vessel problems.
  • Serotonin: affects mood, appetite, sleep, and other functions. It also triggers hormones that affect sexual arousal and trust. The release of large amounts of serotonin likely causes the emotional closeness, elevated mood, and empathy felt by those who use MDMA.

Other health effects include:

  • Nausea
  • Muscle cramping
  • Involuntary teeth clenching
  • Blurred vision
  • Chills
  • Sweating

MDMA’s effects last about 3 to 6 hours, although many users take a second dose as the effects of the first dose begin to fade. Over the week following moderate use of the drug, a person may experience:

  • Irritability
  • Impulsiveness and aggression
  • Depression
  • Sleep problems
  • Anxiety
  • Memory and attention problems
  • Decreased appetite
  • Decreased interest in and pleasure from sex

Some of these effects may be due to the combined use of MDMA with other drugs, especially marijuana.

High doses of Methylenedioxy-methamphetamine can affect the body’s ability to regulate temperature. This can lead to a spike in body temperature that can occasionally result in liver, kidney, or heart failure, or even death.

In addition, because Molly can promote trust and closeness, its use—especially combined with sildenafil (Viagra®)—may encourage unsafe sexual behavior. This increases people’s risk of contracting or transmitting HIV/AIDS or hepatitis.

Typical Molly Percocet Effects

People use ecstasy to feel happy, energetic, and disconnected from reality. Others use it to feel the drug’s hallucinatory effects. It can change how people perceive time. It also affects vision and hearing.

Molly Percocet: Molly Acute Effects

A person may experience the intoxicating effects of MDMA within 45 minutes or so after taking a single dose. Those effects include an enhanced sense of well-being, increased extroversion, emotional warmth, empathy toward others, and a willingness to discuss emotionally charged memories. In addition, people report enhanced sensory perception as a hallmark of the MDMA experience.  However, MDMA can also cause several acute adverse health effects. For example, while fatal overdoses on MDMA are rare, they can potentially be life-threatening—with symptoms including high blood pressure (hypertension), faintness, panic attacks, and in severe cases, a loss of consciousness and seizures.

Molly Percocet: Molly Sub-Acute Effects

Recreational use of MDMA is often characterized by repeated drug taking over several days (binges), followed by periods of no drug-taking. In one animal study, this pattern of use produced irregular heartbeat (arrhythmia) and heart damage. In addition, in the week following the use of the drug, many people report depression, impaired attention and memory, anxiety, aggression, and irritability.

Molly Percocet: What is Percocet?

Percocet is the brand name of an opiate pharmaceutical drug that is usually prescribed to relieve moderate to severe pain, according to the U.S. National Library of Medicine. Percocet is also prescribed to individuals suffering from chronic pain. It contains oxycodone hydrochloride, which influences the brain’s perception of pain, and acetaminophen, which inhibits pain-related chemicals in the brain.

Percocet Drug Addiction may induce serious side effects, and it is one of the most commonly abused prescription drugs. Prescription painkiller abuse is a widespread problem in the US and around the world.

About 52 million Americans older than 12 have used prescription medications nonmedically at some point in their lives. Many become addicted, and that process happens slowly. Some people don’t notice the moment at which they shift from recreational abuse to intense addiction, but when addiction takes hold, it can be serious.

Due to the potential for abuse and addiction with Percocet, the drug’s manufacturer, Endo Pharmaceuticals, states in the prescribing information for Percocet that it is normally reserved for those who are tolerant to other opioids or those who haven’t obtained pain relief from other sources.

An individual can overdose on Percocet if the drug is taken more often than prescribed, if tablets are crushed or chewed, or if it is combined with other sedatives, such as alcohol or sleeping pills. Overdose is considered a medical emergency. Without prompt treatment, serious health effects and even death can occur.

Long-term Percocet drug addiction impacts negatively an individual’s long-term health, as well as their psychological and emotional wellbeing. Thankfully, comprehensive addiction treatment can help individuals safely withdraw from this prescription drug and stop the abuse of all substances.

molly percocet
A Molly Percocet mix can produce adverse physical and psychological reactions. The combination of two different substances also increases the risk of overdose.

Molly Percocet: Effects of Percocet Drug Addiction

Percocet is usually prescribed on a short-term basis, for this reason, an addicted person may eventually resort to illegal means to feed their habit. Percocet Drug Addiction can result in risky behavior, including:

  • Seeking out drug dealers
  • Using a fake prescription
  • Stealing
  • Seeing multiple doctors

Percocet reduces intestinal motility. This often causes constipation and difficulty with bowel movements. Because of the Oxycodone in Percocet, there are numerous potential side effects tied to abuse of the drug. The most commonly recorded physical side effects of Percocet Drug Addiction include:

  • Confusion
  • Mood swings
  • Depression
  • Difficulty sleeping or sleeping too much
  • Low blood pressure
  • Reduced breathing rate
  • Sweating
  • Difficulty with coordination
  • Fatigue
  • Anxiety
  • Diarrhea
  • Abdominal pain
  • Headache
  • Memory loss
  • Dizziness

What Are the Side Effects of Molly Percocet?

A Percocet Molly mix can produce adverse physical and psychological reactions. The combination of two different substances also increases the risk of overdose.

Some common effects of Molly Percocet include:

  • Euphoria
  • Sedation
  • Nausea and vomiting
  • Dry mouth
  • Pinpoint pupils
  • Loss of appetite
  • Shallow breathing
  • Dizziness
  • Stomach pain
  • Constipation
  • Decreased blood pressure
  • Mood swings
  • Memory problems
  • Reduced alertness
  • Impaired judgment
  • Impaired perception of time and surroundings
  • Seizures
  • Convulsions
  • Muscle cramping

High doses of MDMA can also affect the body’s ability to regulate its temperature, increasing the user’s risk of liver, kidney, or heart failure. Additionally, Molly can also promote sociability, trust, and closeness, which can encourage unsafe sexual behavior.

While molly has been a slang word for “drugs” since the 1970s, it referred to the illegal drug MDMA at least by the 2010s, apparently as a shortening of the molecule. MDMA is better known as ecstasy, a euphoria-inducing drug first made in the early 1900s.

The highly addictive Percocet, meanwhile, is a prescription brand of a drug combining oxycodone (hydrochloride) and acetaminophen, two common types of pain-relievers.

Very dangerously, people like to mix molly and Percocet, the latter drug easing the pain of coming down from the former. It’s exactly what the doctor didn’t order.

In April 2017, Atlanta-based rapper Future released his now-platinum single “Mask Off,” which inspired a viral internet video trend, the Mask Off Challenge. The song is about his rise from poverty to success—and use of recreational drugs, as its hook, goes to “Percocets, molly, Percocets / Percocets, molly, Percocets.”

Molly Percocet
Very dangerously, people like to mix molly and Percocet, the latter drug easing the pain of coming down from the former. It’s exactly what the doctor didn’t order.

Thanks to the lyrics, many people came to call the song which reached #5 on the Billboard charts, Molly Percocets or just Molly Percocet. Despite the song going by that name, its words molly and Percocet often get censored on mainstream radio or TV, including Future’s performance of it with Kendrick Lamar at the 2017 BET Awards.

Reclaim Your Life From Molly Percocet

Molly Percocet drug combination is a practice that can cause major health, social, and economic problems that should not be taken lightly. We Level Up Treatment Center can provide you, or someone you love, the tools to recover from addiction and abuse with professional and safe treatment. Feel free to call us to speak with one of our counselors. We can inform you about this condition by giving you relevant information. Our specialists know what you are going through. Please know that each call is private and confidential.


[1] U.S. National Library of Medicine –

[2] The National Institute on Drug Abuse (NIDA) –

[3] U.S. Food and Drug Administration (FDA) –

[4] National Institute on Drug Abuse – Prescription Opioids DrugFacts

[5] We Level Up California – Percocet Drug Addiction

[6] We Level Up Treatment Center – Percocet Addiction

[7] We Level Up Florida – Dangers of Percocet Addiction

[8] National Institute of Drug Abuse – ‘MDMA (Ecstasy/Molly) DrugFacts’ | NIDA (

[9] We Level Up California – What is MDMA?