How Long Does Trazodone Last?

How Long Does Trazodone Last In Your System? While most Trazodone may be eliminated within a few days, individual responses can vary.

What Is Trazodone?

Trazodone is a medication primarily prescribed for its antidepressant properties. Classified as a serotonin antagonist and reuptake inhibitor (SARI), trazodone works by increasing the levels of serotonin, a neurotransmitter, in the brain. Beyond its antidepressant effects, trazodone is commonly used off-label to treat insomnia due to its soothing properties.

Unlike many other antidepressants, trazodone tends to have a milder impact on sexual function, making it a preferred choice for individuals who may experience sexual side effects with other medications.

Table of Trazodone Properties

Primary UseAntidepressant
Secondary UseTreatment of insomnia (off-label)
ClassSerotonin Antagonist and Reuptake Inhibitor (SARI)
Mechanism of ActionIncreases serotonin levels in the brain by blocking serotonin reuptake and acting as a receptor antagonist
Side EffectsSedation, dizziness, dry mouth, blurred vision, constipation, and potential sexual side effects
Unique FeatureRelatively low impact on sexual function compared to other antidepressants
CautionShould be taken as prescribed; abrupt discontinuation may lead to withdrawal symptoms
InteractionsPotential interactions with other medications, particularly those affecting serotonin levels
Trazodone Properties

How Long Does Trazodone Effects Last?

How long does Trazodone last? The duration of Trazodone’s effects can vary among individuals based on factors such as metabolism, dosage, and the specific reason for its use. Trazodone is known for its sedative properties, and its impact on promoting sleep is a common reason for its prescription.

  1. Immediate Release Formulation (for sleep): The immediate-release form of Trazodone is often used to address insomnia. Its sedative effects typically begin within 1 to 2 hours after ingestion. The peak effects are usually reached within a few hours, and the duration of sedation can last up to 6 to 8 hours.
  2. Extended Release Formulation (for depression): When used for the treatment of depression, Trazodone is sometimes prescribed in an extended-release formulation. The effects of the extended-release version can be more sustained, with a gradual onset and a duration that may extend throughout the day.

Responses to Trazodone can vary. Some people may find that the soothing effects help them fall asleep, while others may experience residual drowsiness the next day. Additionally, the dosage prescribed by a healthcare professional determines the intensity and duration of Trazodone’s effects.

How Long Does Trazodone Last In Your System?

How long Trazodone lasts in one’s system can vary from person to person and is influenced by factors such as individual metabolism, dosage, and the specific formulation (immediate release or extended-release). Additionally, other medications or medical conditions can impact the elimination of Trazodone from the body.

  1. Half-Life: The half-life of Trazodone is approximately 5 to 9 hours for the immediate-release formulation and may be longer for the extended-release formulation. The half-life is the time it takes for half of the drug to be eliminated from the body.
  2. Complete Elimination: It typically takes about 5 half-lives for a drug to be mostly eliminated from the system. Therefore, it may take around 1 to 2 days for Trazodone to be primarily cleared from the body.
  3. Individual Variability: The elimination rate can vary among individuals based on age, liver function, kidney function, and other medications.
  4. Detection in Drug Tests: Trazodone is not usually included in standard drug tests, but specific tests for its metabolites can detect its presence. These tests are not commonly administered in routine screenings.

While most Trazodone may be eliminated within a few days, individual responses can vary. If you have concerns about Trazodone’s presence in your system or its potential interactions with other medications, discuss these with your healthcare provider. They can provide personalized guidance based on your health status and the specifics of your treatment plan.

Ryan Zofay forming a circle and hugging friends.

Get Your Life Back

Find Hope & Recovery. Get Safe Comfortable Detox, Addiction Rehab & Dual Diagnosis High-Quality Care.

Hotline (855) 695-1160

Trazodone Half Life

The half life of trazodone is typically in the range of 5 to 9 hours for the immediate-release formulation. The half-life may be longer for the extended-release formulation, reaching up to 10 hours or more. However, individual variations can influence the rate at which trazodone is metabolized and eliminated.

As a general guideline, it may take about 1 to 2 days for trazodone to be cleared from the body after discontinuation. However, there are a few factors that can affect how fast that happens.

Factors That Affect How Long Trazodone Stays in Your Body

  1. Dosage and Formulation: The dose of trazodone and whether it is an immediate-release or extended-release formulation can impact its concentration in the body.
  2. Individual Metabolism: Each person’s metabolism is unique, affecting how quickly the body processes and eliminates trazodone. Metabolic rates can be influenced by genetics, age, and overall health.
  3. Liver Function: Trazodone is primarily metabolized in the liver. Individuals with compromised liver function may metabolize trazodone more slowly, potentially prolonging its presence in the body.
  4. Kidney Function: While the kidneys are not the primary route of elimination for trazodone, they play a role in excreting some metabolites. Impaired kidney function may affect the drug’s clearance.
  5. Age: Older individuals, in general, may metabolize drugs more slowly than younger individuals, potentially extending the duration trazodone stays in the body.
  6. Drug Interactions: Other medications taken concurrently can influence trazodone metabolism. Some drugs may inhibit or induce the enzymes responsible for trazodone metabolism, affecting its clearance.
  7. Hydration Status: Adequate hydration supports the body’s natural processes, including drug elimination. Dehydration can potentially impact how long trazodone stays in the body.
  8. Overall Health: The general health of an individual can impact drug metabolism. Conditions affecting metabolism or organ function may alter the drug’s elimination rate.
  9. Genetic Factors: Genetic variations can contribute to differences in drug metabolism among individuals.

Get Help. Get Better. Get Your Life Back.

Searching for an Accredited Drug and Alcohol Rehab Centers in Near You?

Even if you have failed previously and relapsed, or are in the middle of a difficult crisis, we stand ready to support you. Our trusted behavioral health specialists will not give up on you. When you feel ready or just want someone to speak to about therapy alternatives to change your life call us. Even if we cannot assist you, we will lead you to wherever you can get support. There is no obligation. Call our hotline today.

FREE Addiction Hotline – Call 24/7
Does Trazodone Show Up On A Drug Test? While Trazodone does not show up on routine drug tests, there are specific tests designed to detect Trazodone in your system. Such tests are only conducted if there is a specific reason for it.

Does Trazodone Show Up On A Drug Test?

Trazodone is not typically included in standard drug tests that are commonly used for employment screenings or other routine drug testing purposes. These tests usually focus on detecting common illicit drugs such as marijuana, cocaine, opioids, amphetamines, and benzodiazepines.

However, specific tests designed to detect trazodone or its metabolites can be conducted if there is a specific reason to screen for this medication. These tests are not part of routine drug screenings and are generally reserved for situations where the use of trazodone is of particular concern, such as in forensic or clinical settings.

If you have upcoming drug testing and are taking trazodone, it is advisable to inform the testing facility or the individual conducting the test about your prescription medications. Providing this information ensures that any potential detection of trazodone is appropriately interpreted in the context of prescribed medical treatment.

Always follow the guidance of your healthcare provider and inform them of all medications, including prescription and over-the-counter drugs, that you are taking to ensure safe and effective healthcare management.

How Long Does Trazodone Stay In Your System For A Drug Test?

How long trazodone remains in your system can be affected by different factors, such as individual metabolism, dosage, and the specific formulation of the medication. The immediate-release formulation of trazodone has a half-life of around 5 to 9 hours, and the extended-release formulation may have a longer half-life.

As a rule of thumb, it typically requires about 5 half-lives for a drug to be predominantly eliminated from the body. Consequently, in the case of immediate-release trazodone, it might take roughly 1 to 2 days for the medication to be mostly cleared from the system after discontinuation.

Comfortable Facilities & Amenities

High-Quality Addiction & Mental Health Rehabilitation Treatment

Rehab Centers Tour

Renowned California Addiction Center. Serene Private Facilities. Inpatient rehab programs vary.

Addiction Helpline (855) 695-1160

Proven recovery success experience, backed by a Team w/ History of:


Years of Unified Experience


5-Star Reviews Across Our Centers


Recovery Success Stories Across Our Network

  • Low Patient to Therapist Ratio
  • Onsite Medical Detox Center
  • Comprehensive Dual-Diagnosis Treatment
  • Complimentary Family & Alumni Programs
  • Coaching, Recovery & Personal Development Events

Is Trazodone Addictive?

Trazodone is generally considered to have a lower potential for abuse and addiction compared to some other medications used to treat depression or anxiety. It is not classified as a controlled substance by the United States Drug Enforcement Administration (DEA).

However, like many medications, trazodone should be used under the guidance of a healthcare professional and according to the prescribed dosage. Abruptly stopping trazodone or changing the dosage without medical supervision can lead to withdrawal symptoms or a return of depressive symptoms.

While trazodone is not typically associated with the same risk of addiction as some other medications, individuals need to follow their healthcare provider’s instructions carefully and communicate openly about any concerns or side effects. If there are concerns about dependence or potential interactions with other substances, discussing them with a healthcare professional is crucial for appropriate guidance and management.

Can You Get Withdrawal from Trazodone?

Abruptly stopping or rapidly reducing the dosage of trazodone can lead to withdrawal symptoms, especially when Trazodone has been taken for a long time. Individuals taking trazodone should follow their healthcare provider’s guidance on dosage changes and, if needed, the gradual tapering of the medication to avoid withdrawal effects.

Withdrawal symptoms from trazodone can include:

  1. Insomnia: Trazodone is commonly prescribed for its soothing effects, and withdrawal may lead to difficulty sleeping.
  2. Anxiety or Agitation: Some individuals may experience heightened anxiety or restlessness during withdrawal.
  3. Mood Changes: Changes in mood, including irritability or mood swings, can occur.
  4. Flu-Like Symptoms: Headache, nausea, dizziness, and flu-like symptoms may be experienced by some individuals.
  5. Electric Shock Sensations: Referred to as “brain zaps” or “electric shock sensations,” these can be unique withdrawal symptoms associated with certain antidepressant medications, including trazodone.

Withdrawal symptoms can vary among individuals, and not everyone will experience them. To mitigate the risk of withdrawal, healthcare providers typically recommend a gradual tapering of trazodone rather than sudden discontinuation, especially if the medication has been used for an extended period or at higher doses.

If you are considering discontinuing trazodone or have concerns about potential withdrawal symptoms, discuss this with your healthcare provider. They can guide an appropriate tapering schedule and monitor your response to changes in medication to ensure a safe and smooth transition.

World-class, Accredited, 5-Star Reviewed, Effective Addiction & Mental Health Programs. Complete Behavioral Health Inpatient Rehab, Detox plus Co-occuring Disorders Therapy.

CALL (855) 695-1160

End the Addiction Pain. End the Emotional Rollercoaster. Get Your Life Back. Start Drug, Alcohol & Dual Diagnosis Mental Health Treatment Now. Get Free No-obligation Guidance by Substance Abuse Specialists Who Understand Addiction & Mental Health Recovery & Know How to Help.

Trazodone Overdose

A trazodone overdose can occur when an individual takes more of the medication than prescribed or recommended, leading to the ingestion of a toxic amount. Overdosing on trazodone can result in severe and potentially life-threatening complications. If you suspect a trazodone overdose, seek emergency medical attention immediately.

Symptoms of a trazodone overdose may include:

  1. Drowsiness or Sedation: Trazodone is known for its soothing effects, and an overdose can lead to excessive drowsiness or sedation.
  2. Confusion: Overdose may cause confusion, disorientation, or difficulty concentrating.
  3. Dizziness or Fainting: A trazodone overdose can lead to a drop in blood pressure, resulting in dizziness or fainting.
  4. Irregular Heartbeat: Overdose may cause changes in heart rate or rhythm, including an irregular heartbeat.
  5. Seizures: In severe cases, seizures may occur.
  6. Difficulty Breathing: Overdose can affect respiratory function, leading to difficulty breathing.

If you or someone else is experiencing symptoms of a trazodone overdose, it is essential to seek immediate medical attention. Contact your local emergency services or go to the nearest emergency room.

It’s important to note that the information provided here is for general knowledge, and any specific concerns or questions about trazodone, including potential overdose risks, should be discussed with a healthcare professional. Always take medications as prescribed, and never exceed the recommended dosage without consulting your healthcare provider.

Experience Transformative Recovery at the We Level Up California Treatment Center.

See our authentic success stories. Get inspired. Get the help you deserve.

We Level Up Treatment Centers for Drug Alcohol Rehab Detox Behavioral Mental Health Dual Diagnosis Therapy We Level Up Treatment Centers for Drug Alcohol Rehab Detox Behavioral Mental Health Dual Diagnosis Therapy We Level Up Treatment Centers for Drug Alcohol Rehab Detox Behavioral Mental Health Dual Diagnosis Therapy
Hotline (855) 695-1160
Voluntarily testimonials from the We Level Up Treatment Center network vary. Not intended as a guaranteed treatment or outcome as each person's journey is unique.

Start a New Life

Begin with a free call to an addiction & behavioral health treatment advisor. Learn more about our dual-diagnosis programs. The We Level Up treatment center network delivers recovery programs that vary by each treatment facility. Call to learn more.

  • Personalized Care
  • Caring Accountable Staff
  • World-class Amenities
  • Licensed & Accredited
  • Renowned w/ 100s 5-Star Reviews

We’ll Call You

Clinical Depression / Depression Symptoms / Signs of Depression / Major Depressive Disorder Help

Search Drug & Alcohol Rehab / Detox & Mental Health Topics & Resources

  1. MedlinePlus, National Library of Medicine (NLM). Trazodone.
  2. Shin JJ, Saadabadi A. Trazodone. [Updated 2022 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:
  3. Food and Drug Administration (FDA). DESYREL® (trazodone hydrochloride).
  4. Food and Drug Administration (FDA). Depression Medicines.
  5. Jaffer KY, Chang T, Vanle B, Dang J, Steiner AJ, Loera N, Abdelmesseh M, Danovitch I, Ishak WW. Trazodone for Insomnia: A Systematic Review. Innov Clin Neurosci. 2017 Aug 1;14(7-8):24-34. PMID: 29552421; PMCID: PMC5842888.
  6. Fagiolini A, Comandini A, Catena Dell’Osso M, Kasper S. Rediscovering trazodone for the treatment of major depressive disorder. CNS Drugs. 2012 Dec;26(12):1033-49. doi: 10.1007/s40263-012-0010-5. Erratum in: CNS Drugs. 2013 Aug;27(8):677. PMID: 23192413; PMCID: PMC3693429.
  7. Fagiolini A, González-Pinto A, Miskowiak KW, Morgado P, Young AH, Vieta E. Role of trazodone in treatment of major depressive disorder: an update. Ann Gen Psychiatry. 2023 Sep 2;22(1):32. doi: 10.1186/s12991-023-00465-y. PMID: 37660092; PMCID: PMC10474647.
  8. Sheffler ZM, Patel P, Abdijadid S. Antidepressants. [Updated 2023 May 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: