Vyvanse Withdrawal Symptoms, Timeline, & Treatment, A Guide

Vyvanse Withdrawal happens when one stops taking Vyvanse after becoming dependent on the drug. Lisdexamfetamine treats ADHD and BED.

A prescription drug called Vyvanse is used to help treat and lessen symptoms associated with ADHD. Lisdexamfetamine is what is known as the brand name Vyvanse. Being a prodrug, it is made to allow the body to absorb the medication gradually and slowly. This gradual absorption also delays how fast someone taking Vyvanse will feel the effects. This design was made to deter misuse of the medicine.

Yet, even pushing aside misuse, someone properly following their prescription is still at risk of experiencing withdrawals once the treatment is completed or if they suddenly stop using. It may be scary to experience such unexpected symptoms or side effects suddenly, but knowing is half the battle. Check out the rest of the article to learn more about Vyvanse withdrawal.

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Vyvanse Withdrawal Symptoms

Vyvanse is addictive despite being effective for the treatment of ADHD and BED (Binge Eating Disorder). It is easy to become psychologically and physically dependent on it. When a person is reliant on a medication, abruptly discontinuing treatment might result in withdrawal symptoms. These symptoms might be severe or moderate, depending on the individual.

  • Fatigue: Feeling extremely tired or lethargic.
  • Increased Appetite: Some people may experience an increase in appetite.
  • Mood Changes: Mood swings, irritability, or depression.
  • Sleep Disturbances: Changes in sleep patterns, such as insomnia or excessive sleep.
  • Difficulty Concentrating: Difficulty focusing or paying attention.
  • Cravings: An intense desire for the medication.

Some severe symptoms can include:

  • Suicidal behaviors and ideation.
  • Psychosis.

Explore Vyvanse’s side effects here:

Vyvanse Withdrawal Timeline

How Long Does Vyvanse Withdrawal Last?

The Vyvanse withdrawal timeline is based on an individual’s health factors and general circumstances. Generally, it can begin within several days of the last dose and last for up to and beyond two weeks.

First 24-72 hours

People experience a crash when the effects of Vyvanse begin to wear off. This is not yet considered Vyvanse withdrawal, but it can certainly set the ball rolling.


  • Fatigue and lethargy.
  • Increased appetite.
  • Mood swings, irritability, or anxiety.

First week

After the initial effects of the crash, the actual withdrawal starts. At this point, the brain is trying to adjust to life without the effects of Vyvanse.


  • Continued fatigue.
  • Difficulty concentrating.
  • Changes in sleep patterns (insomnia or excessive sleep).
  • Cravings for the medication.

First two weeks

For most people, the withdrawal symptoms end after this period.


  • Gradual improvement in mood.
  • Stabilization of appetite.
  • Sleep patterns may begin to normalize.

Beyond two weeks

Sometimes, others will still feel some residual effects from Vyvanse. This mostly happens when the individual has been taking Vyvanse long.


  • Residual symptoms may persist but generally decrease in intensity.
  • Emotional and cognitive functioning may continue to improve.
  • Individual variations in the duration and severity of symptoms.

Managing Symptoms of Vyvanse Withdrawal

Tapering down your use of Vyvanse, whether therapeutically or recreationally, is the best method to handle these withdrawal symptoms.

Tapering your use means progressively decreasing the amount of medication you consume until you’re able to stop taking Vyvanse safely and without risk of withdrawal. This practice is done so that your body can become accustomed to running on its own without or with reduced aid from the drug’s effects.

This practice is only recommended to be done under medical supervision. Doing this on your own can cause significant risks and severe complications.

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Quitting Vyvanse Cold Turkey

It might be possible to quit Vyvanse cold turkey due to its long half-life, but it is highly reliant on dosage. Regardless, consult your doctor before stopping your Vyvanse prescription.
It might be possible to quit Vyvanse cold turkey due to its long half-life, but it is highly reliant on dosage. Regardless, consult your doctor before stopping your Vyvanse prescription.

Vyvanse stands out among psychoactive drugs as it is one of the few that may allow for abrupt discontinuation without a taper. This unique characteristic is attributed to its extended half-life, lasting between 8.6 to 11.3 hours, resulting in a gradual decline in its effects.

Even if you suddenly discontinue Vyvanse, your system may take up to a week to completely eliminate it. However, individual circumstances vary, and your doctor may recommend a tapering approach based on factors such as dosage and any previous experiences with withdrawal symptoms.

This is particularly applicable when using Vyvanse at larger doses, as it may increase the likelihood of withdrawal symptoms following discontinuation.

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Vyvanse Withdrawal Treatment

Treatment for Vyvanse withdrawal often includes a systematized process, which a medical professional often oversees. The goal is to make the transition as easy as possible while minimizing the severity of withdrawal symptoms.

Tapering Off the Medication

This is the gradual reduction of the dosage of the individual’s Vyvanse prescription. This is done over a set timeline designed to help the body adjust.

Medical Supervision

During tapering, healthcare specialists such as psychiatrists or primary care physicians monitor the individual’s progress. Depending on the patient’s response and overall well-being, they may change the tapering timetable and progress.

Symptom Management

Managing specific withdrawal symptoms as they develop may entail using drugs to control mood swings, anxiety, or sleep difficulties.

Supportive Therapy

Counseling or therapy might help those dealing with the emotional and psychological components of withdrawal. It provides a safe space to discuss problems, develop coping techniques, and set realistic goals.

Lifestyle Adjustments

During the withdrawal process, maintaining a healthy lifestyle might help the individual’s overall well-being. A healthy lifestyle can include frequent exercise, a well-balanced diet, and appropriate sleep.

Patient Education

Information about what to expect from the withdrawal process could make them feel more empowered and less anxious. It can be comforting to know that specific symptoms are only transient and are part of the adjustment process.

The goal of Vyvanse withdrawal symptoms treatment is to make the transition to life without Vyvanse as easy as possible while minimizing the severity of withdrawal symptoms.
The goal of Vyvanse withdrawal symptoms treatment is to make the transition to life without Vyvanse as easy as possible while minimizing the severity of withdrawal symptoms.

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Vyvanse Detox

Tolerance to stimulants like Vyvanse can develop quickly, requiring greater doses to produce the same results. Tolerance almost always leads to dependence. Dependence indicates that if a person abruptly discontinues using Vyvanse, they would most likely experience withdrawal symptoms.

The Vyvanse Detoxification process supports the body as it adjusts to the lack of Vyvanse while reducing potential problems. It is usually done under the supervision of a healthcare practitioner to ensure a safe and effective transition.

The Vyvanse Detoxification process supports the body as it adjusts to the lack of Vyvanse while reducing potential problems.
The Vyvanse Detoxification process supports the body as it adjusts to the lack of Vyvanse while reducing potential problems.

Vyvanse Detox Timeline

Time FrameDetox Milestones and Symptoms
Days 1-3Initial Withdrawal: Fatigue, irritability, and cravings may set in. Sleep patterns may be disrupted.
Days 4-7Intensified Symptoms: Cravings may persist, along with heightened mood swings, anxiety, and increased appetite.
Week 2Stabilization: Physical symptoms begin to subside, but psychological aspects like mood swings and cravings may persist.
Weeks 3-4Sustained Progress: Emotional well-being stabilizes further. Focus on long-term recovery with ongoing support and lifestyle adjustments.
Months 1-3Emotional Stability: Gradual improvement in mood and cognitive function. Continued support and coping strategies are essential.
Months 3-6Sustained Progress: Emotional well-being stabilizes further. Focus on long-term recovery, with ongoing support and lifestyle adjustments.
Beyond 6 MonthsMaintenance: Continued vigilance against triggers. Emphasis on a healthy lifestyle and ongoing support to prevent relapse.
Vyvanse Detox Timeline

How Long Does it Take to Detox From Vyvanse?

People who stop using Vyvanse and develop withdrawal symptoms may discover that their symptoms begin within a few days of their last Vyvanse dose. Most Vyvanse withdrawal symptoms will go away within two weeks. A Vyvanse detox regimen might last anywhere from a few days to weeks.

Learn more about the Vyvanse Detoxification Process here:

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